a) Vincenzo Natali was growing up when Alien came out and it meant a lot to him to know as much about it as possible before he finally got to see it
(SEE: Vincenzo Natali and the Alien)
b) He was said to have been planning to direct an Alien movie but it never came into being
(SEE: Sigourney's Dreams of continuing Alien)
c) One of his major concepts, people trapped in a puzzle box environment from his own films appeared to be absorbed into the Alien vs Predator movie.
(SEE: Aliens in puzzle box pyramid)
d) When the movie Splice came out, he was able to openly acknowledge what influence the Alien movies had on the film.
(SEE: Splice/Alien comparisons)
e) In 2014, Vincenzo went on to direct the first seven episodes of season 3 of Hannibal. The "Stagenstein sequence" from episode 2 displayed some similarities to the Alien as a Box sequence seen in the Alien: Illustrated Story by Walter Simonson.
(SEE: Vincenzo Natali's Stagenstein sequence from Hannibal season 3, episode 2 )